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KMID : 1140220200250030136
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대한암예방학회지
2020 Volume.25 No. 3 p.136 ~ p.151
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Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
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Gomathinayagam Rohini
Ha Ji-Hee
Jayaraman Muralidharan
Song Yong-Sang
Isidoro Ciro
Dhanasekaran Danny N.
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Abstract
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Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.
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KEYWORD
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Nigella sativa, Thymoquinone, Neoplasms, Chemoprevention, Antineoplastic agent
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